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Heritability and Genome-Wide Association Analyses of Sleep Duration in Children: The EAGLE Consortium.

Authors :
Marinelli, Marcella
Pappa, Irene
Bustamante, Mariona
Bonilla, Carolina
Suarez, Anna
Tiesler, Carla M
Vilor-Tejedor, Natalia
Zafarmand, Mohammad Hadi
Alvarez-Pedrerol, Mar
Andersson, Sture
Bakermans-Kranenburg, Marian J
Estivill, Xavier
Evans, David M
Flexeder, Claudia
Forns, Joan
Gonzalez, Juan R
Guxens, Monica
Huss, Anke
van IJzendoorn, Marinus H
Jaddoe, Vincent W V
Julvez, Jordi
Lahti, Jari
López-Vicente, Mónica
Lopez-Espinosa, Maria-Jose
Manz, Judith
Mileva-Seitz, Viara R
Perola, Markus
Pesonen, Anu-Katriina
Rivadeneira, Fernando
Salo, Perttu P
Shahand, Shayan
Schulz, Holger
Standl, Marie
Thiering, Elisabeth
Timpson, Nicholas J
Torrent, Maties
Uitterlinden, André G
Smith, George Davey
Estarlich, Marisa
Heinrich, Joachim
Räikkönen, Katri
Vrijkotte, Tanja G M
Tiemeier, Henning
Sunyer, Jordi
Source :
Sleep; October 2016, Vol. 39 Issue: 10 p1859-1869, 11p
Publication Year :
2016

Abstract

Low or excessive sleep duration has been associated with multiple outcomes, but the biology behind these associations remains elusive. Specifically, genetic studies in children are scarce. In this study, we aimed to: (1) estimate the proportion of genetic variance of sleep duration in children attributed to common single nucleotide polymorphisms (SNPs), (2) identify novel SNPs associated with sleep duration in children, and (3) investigate the genetic overlap of sleep duration in children and related metabolic and psychiatric traits.

Details

Language :
English
ISSN :
01618105 and 15509109
Volume :
39
Issue :
10
Database :
Supplemental Index
Journal :
Sleep
Publication Type :
Periodical
Accession number :
ejs51405773
Full Text :
https://doi.org/10.5665/sleep.6170