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Potentiation of Pressor Effects of Noradrenaline and Potassium Ions in the Rat Mesenteric Arteries by Physiological Concentrations of Angiotensin II: Effects of Prostaglandin E2 and Cortisol
- Source :
- Clinical Science; September 1977, Vol. 53 Issue: 3 p233-239, 7p
- Publication Year :
- 1977
-
Abstract
- 1. In the perfused rat mesenteric vascular bed, the effects of angiotensin II, cortisol and prostaglandin E2 on the vascular responses to noradrenaline or potassium chloride were studied. 2. Angiotensin II in subpressor concentrations potentiated the vasoconstrictor response to noradrenaline and potassium chloride. This effect of angiotensin II was inhibited in the presence of indomethacin and prostaglandin E2. 3. Cortisol in physiological concentrations inhibited the potentiating effect of angiotensin II. 4. Prostaglandin E2 enhanced the vasoconstrictor response to noradrenaline. This effect was not abolished by cortisol. 5. These results suggest that some actions of angiotensin II and cortisol in vivo are mediated by the regulation of prostaglandin synthesis or release.
Details
- Language :
- English
- ISSN :
- 01435221 and 14708736
- Volume :
- 53
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Clinical Science
- Publication Type :
- Periodical
- Accession number :
- ejs51343255
- Full Text :
- https://doi.org/10.1042/cs0530233