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Immunoglobulin-binding domains: Protein L from Peptostreptococcus magnus
- Source :
- Biochemical Society Transactions; June 2003, Vol. 31 Issue: 3 p716-718, 3p
- Publication Year :
- 2003
-
Abstract
- Protein L is a multidomain cell-wall protein isolated from Peptostreptococcus magnus. It belongs to a group of proteins that contain repeated domains that are able to bind to Igs without stimulating an immune response, the most characterized of this group being Protein A (Staphylococcus aureus) and Protein G (Streptococcus). Both of these proteins bind predominantly to the interface of CH2-CH3 heavy chains, while Protein L binds exclusively to the VL domain of the κ-chain. The function of these proteins in vivo is not clear but it is thought that they enable the bacteria to evade the host's immune system. Two binding sites for κ-chain on a single Ig-binding domain from Protein L have recently been reported and we give evidence that one site has a 25–55-fold higher affinity for κ-chain than the second site.
Details
- Language :
- English
- ISSN :
- 03005127 and 14708752
- Volume :
- 31
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Biochemical Society Transactions
- Publication Type :
- Periodical
- Accession number :
- ejs51267420
- Full Text :
- https://doi.org/10.1042/bst0310716