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DLK1 Is a Novel Link Between Reproduction and Metabolism.

Authors :
Gomes, Larissa G
Cunha-Silva, Marina
Crespo, Raiane P
Ramos, Carolina O
Montenegro, Luciana R
Canton, Ana
Lees, Melissa
Spoudeas, Helen
Dauber, Andrew
Macedo, Delanie B
Bessa, Danielle S
Maciel, Gustavo A
Baracat, Edmund C
Jorge, Alexander A L
Mendonca, Berenice B
Brito, Vinicius N
Latronico, Ana Claudia
Source :
The Journal of Clinical Endocrinology & Metabolism; June 2019, Vol. 104 Issue: 6 p2112-2120, 9p
Publication Year :
2019

Abstract

Delta-like homolog 1 (DLK1), also called preadipocyte factor 1, prevents adipocyte differentiation and has been considered a molecular gatekeeper of adipogenesis. A DLK1 complex genomic defect was identified in five women from a single family with central precocious puberty (CPP) and increased body fat percentage.

Details

Language :
English
ISSN :
0021972X and 19457197
Volume :
104
Issue :
6
Database :
Supplemental Index
Journal :
The Journal of Clinical Endocrinology & Metabolism
Publication Type :
Periodical
Accession number :
ejs51162363
Full Text :
https://doi.org/10.1210/jc.2018-02010