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Sustained release of vancomycin from a new biodegradable glue to prevent methicillin-resistant Staphylococcus aureus graft infection.
- Source :
- Interactive Cardiovascular and Thoracic Surgery; July 2010, Vol. 11 Issue: 1 p52-55, 4p
- Publication Year :
- 2010
-
Abstract
- Prosthetic graft infection with methicillin-resistant Staphylococcus aureus (MRSA) is one of the most serious complications of cardiovascular surgery. Seeking to prevent graft infection, we evaluated the efficacy of a new biodegradable hydrogel glue (new-glue) composed of aldehyded dextran and epsilon-poly(L-lysine) which acts as a local sustained-release carrier of vancomycin. Rats (n=40) were implanted with 1-cm(2) Dacron grafts in the subcutaneous pockets. Groups (n=10 each) were as follows: no treatment (group A), topical vancomycin solution (group B), new-glue without vancomycin (group C) or new-glue containing 1 mg of vancomycin (group D). Twenty-four h after the implantation, 2.0x10(7) colony-forming units of MRSA was inoculated onto the graft surface. Seven days thereafter, the graft was sampled and cultured. The quantity of MRSA was significantly lower in group D than in the other groups (P<0.0001). About 95% of the total vancomycin was released from the new-glue over the 72 h experimental period, and the tissue concentration of vancomycin remained above the minimum inhibitory concentration for the MRSA strain throughout the experiment. This new vancomycin-containing glue effectively prevented prosthetic graft infection and thus may be a promising biodegradable drug vehicle.
Details
- Language :
- English
- ISSN :
- 15699293 and 15699285
- Volume :
- 11
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Interactive Cardiovascular and Thoracic Surgery
- Publication Type :
- Periodical
- Accession number :
- ejs51138668
- Full Text :
- https://doi.org/10.1510/icvts.2010.232447