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Synthesis and Cytotoxicities of Novel Podophyllotoxin Xyloside Derivatives
- Source :
- Natural Product Communications; July 2019, Vol. 14 Issue: 7
- Publication Year :
- 2019
-
Abstract
- Novel podophyllotoxin xyloside derivatives 8to 11were synthesized and evaluated for their cytotoxicities against a panel of 5 human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480) using [3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide] assays. These derivatives showed good to moderate activities, with compound 9having an IC50value of 4.42 μM against the A-549 cell line. Overall, compound 9might be a promising candidate for further development.
Details
- Language :
- English
- ISSN :
- 1934578X and 15559475
- Volume :
- 14
- Issue :
- 7
- Database :
- Supplemental Index
- Journal :
- Natural Product Communications
- Publication Type :
- Periodical
- Accession number :
- ejs50707202
- Full Text :
- https://doi.org/10.1177/1934578X19860668