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Norursodeoxycholic acid versus placebo in the treatment of non-alcoholic fatty liver disease: a double-blind, randomised, placebo-controlled, phase 2 dose-finding trial

Authors :
Traussnigg, Stefan
Schattenberg, Jörn M
Demir, Münevver
Wiegand, Johannes
Geier, Andreas
Teuber, Gerlinde
Hofmann, Wolf Peter
Kremer, Andreas E
Spreda, Frank
Kluwe, Johannes
Petersen, Jörg
Boettler, Tobias
Rainer, Florian
Halilbasic, Emina
Greinwald, Roland
Pröls, Markus
Manns, Michael P
Fickert, Peter
Trauner, Michael
Vogel, Wolfgang
Aigner, Elmar
Datz, Christian
Tilg, Herbert
Gerken, Guido
Rust, Christian
Cordes, Hans-Jörg
Steib, Christian
Pathil-Warth, Anita
Prinz, Christian
Lammert, Frank
Antoni, Christoph
Klausmann, Gerhard
Häussinger, Dieter
Zipprich, Alexander
Source :
The Lancet Gastroenterology & Hepatology; October 2019, Vol. 4 Issue: 10 p781-793, 13p
Publication Year :
2019

Abstract

Norursodeoxycholic acid is an orally administered side chain-shortened homologue of ursodeoxycholic acid that undergoes hepatic enrichment with hepatoprotective, anti-inflammatory, and antifibrotic activity. We assessed the efficacy of two doses of norursodeoxycholic acid versus placebo for the treatment of non-alcoholic fatty liver disease.

Details

Language :
English
ISSN :
24681253
Volume :
4
Issue :
10
Database :
Supplemental Index
Journal :
The Lancet Gastroenterology & Hepatology
Publication Type :
Periodical
Accession number :
ejs50656612
Full Text :
https://doi.org/10.1016/S2468-1253(19)30184-0