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Accelerated and scarless wound repair by a multicomponent hydrogel through simultaneous activation of multiple pathways
- Source :
- Drug Delivery and Translational Research; December 2019, Vol. 9 Issue: 6 p1143-1158, 16p
- Publication Year :
- 2019
-
Abstract
- Scarless healing of injury remains a clinical challenge because of its complicated and overlapping phases of inflammation, clearing, and regeneration. Curcumin has been already established as a potential wound healing agent for normal and diabetic-impaired wounds. Herein, the question has been addressed whether a well-known antioxidant cerium oxide nanoparticle (CNP) can potentiate the activity of curcumin to promote a cellular program for scarless healing. In this study, we have developed a biocompatible poly (acrylamide) hydrogel (PAGE)-based dressing material comprising of CNP and curcumin (ACC) and tested its wound healing activity in an animal model of acute wound. Characterization of the CNP- and curcumin-entrapped hydrogel dressing (ACC) demonstrated high loading efficiency and sustained release of curcumin. In a full-thickness acute wound healing model of rat, a single application of ACC dressing demonstrated higher wound healing efficacy (78%) and negligible scarring compared to dressings containing only curcumin or CNP in 7 days. Enhanced cell proliferation, higher collagen content, advanced wound maturity, re-epithelialization, and granulation tissue formation were observed using the combination of curcumin and CNP (ACC). Study of cellular mechanisms identified MCP-1 and TGF-β as the key drivers of differential and accelerated healing observed in the ACC group. These, coupled with the upregulation of growth-related signaling pathways (HER2/ErbB2, TGF-β-Smad2/3, MAPK/ERK, AKT, and VEGF), promoted almost scarless healing in animals treated with ACC. The optimized combination of curcumin and CNP used in our study shows distinct advantage and can be a better agent for complete wound healing.
Details
- Language :
- English
- ISSN :
- 2190393x and 21903948
- Volume :
- 9
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Drug Delivery and Translational Research
- Publication Type :
- Periodical
- Accession number :
- ejs50619044
- Full Text :
- https://doi.org/10.1007/s13346-019-00660-z