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Prolonged Esophagitis After Primary Dysfunction of the Pyloric Sphincter in the Rat and Therapeutic Potential of the Gastric Pentadecapeptide BPC 157

Authors :
Dobric, Ivan
Drvis, Petar
Petrovic, Igor
Shejbal, Drazen
Brcic, Luka
Blagaic, Alenka Boban
Batelja, Lovorka
Sever, Marko
Kokic, Neven
Tonkic, Ante
Zoricic, Ivan
Mise, Sandro
Staresinic, Mario
Radic, Bozo
Jakir, Ana
Babel, Jaksa
Ilic, Spomenko
Vuksic, Tihomir
Jelic, Ivan
Anic, Tomislav
Seiwerth, Sven
Sikiric, Predrag
Source :
Journal of Pharmacological Sciences; January 2007, Vol. 104 Issue: 1 p7-18, 12p
Publication Year :
2007

Abstract

Seven or fourteen days or twelve months after suturing one tube into the pyloric sphincter (removed by peristalsis by the seventh day), rats exhibit prolonged esophagitis with a constantly lowered pressure not only in the pyloric, but also in the lower esophageal sphincter and a failure of both sphincters. Throughout the esophagitis experiment, gastric pentadecapeptide BPC 157 (PL 14736) is given intraperitoneally once a day (10 µg/kg, 10 ng/kg, last application 24 h before assessment), or continuously in drinking water at 0.16 µg/ml, 0.16 ng/ml (12 ml/rat per day), or directly into the stomach 5 min before pressure assessment (a water manometer connected to the drainage port of a Foley catheter implanted into the stomach either through an esophageal or duodenal incision). This treatment alleviates i) the esophagitis (macroscopically and microscopically, at either region or interval), ii) the pressure in the pyloric sphincter, and iii) the pressure in the lower esophageal sphincter (cmH2O). In the normal rats it increases lower esophageal sphincter pressure, but decreases the pyloric sphincter pressure. Ranitidine, given using the same protocol (50 mg/kg, intraperitoneally, once daily; 0.83 mg/ml in drinking water; 50 mg/kg directly into the stomach) does not have an effect in either rats with esophagitis or in normal rats.

Details

Language :
English
ISSN :
13478613 and 13478648
Volume :
104
Issue :
1
Database :
Supplemental Index
Journal :
Journal of Pharmacological Sciences
Publication Type :
Periodical
Accession number :
ejs50444501
Full Text :
https://doi.org/10.1254/jphs.FP0061322