Pathogenic Mannheimia haemolyticaInvades Differentiated Bovine Airway Epithelial Cells

The Gram-negative bacterium Mannheimia haemolyticais the primary bacterial species associated with bovine respiratory disease (BRD) and is responsible for significant economic losses to livestock industries worldwide. Healthy cattle are frequently colonized by commensal serotype A2 strains, but disease is usually caused by pathogenic strains of serotype A1.