A single tyrosine phosphorylation site in cortactin is important for filopodia formation in neuronal growth cones

Here, we identified a single tyrosine residue, Y499, in Aplysiacortactin that can be phosphorylated by Src2 and is important for filopodia formation in neuronal growth cones. Phosphorylated cortactin is enriched along the leading edge and filopodia and regulates both filopodia formation and elongation.