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TGF-β type 2 receptor–mediated modulation of the IL-36 family can be therapeutically targeted in osteoarthritis
- Source :
- Science Translational Medicine; May 2019, Vol. 11 Issue: 491
- Publication Year :
- 2019
-
Abstract
- TGFBR2 regulates IL-36 to contribute to joint homeostasis, and an IL-36 receptor antagonist can ameliorate osteoarthritis in mouse models.
Details
- Language :
- English
- ISSN :
- 19466234 and 19466242
- Volume :
- 11
- Issue :
- 491
- Database :
- Supplemental Index
- Journal :
- Science Translational Medicine
- Publication Type :
- Periodical
- Accession number :
- ejs50005512
- Full Text :
- https://doi.org/10.1126/scitranslmed.aan2585