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Oxytocin antagonism prevents pregnancy-associated aortic dissection in a mouse model of Marfan syndrome

Authors :
Habashi, Jennifer Pardo
MacFarlane, Elena Gallo
Bagirzadeh, Rustam
Bowen, Caitlin
Huso, Nicholas
Chen, Yichun
Bedja, Djahida
Creamer, Tyler J.
Rykiel, Graham
Manning, Maurice
Huso, David
Dietz, Harry C.
Source :
Science Translational Medicine; May 2019, Vol. 11 Issue: 490
Publication Year :
2019

Abstract

Protection from pregnancy-associated aortic dissection is achieved by decreasing oxytocin-induced ERK signaling in a mouse model of Marfan syndrome.

Details

Language :
English
ISSN :
19466234 and 19466242
Volume :
11
Issue :
490
Database :
Supplemental Index
Journal :
Science Translational Medicine
Publication Type :
Periodical
Accession number :
ejs49949918
Full Text :
https://doi.org/10.1126/scitranslmed.aat4822