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The Integration of Goal-Directed Signals onto Spatial Maps of Hippocampal Place Cells
- Source :
- Cell Reports; April 2019, Vol. 27 Issue: 5 p1516-1527.e5
- Publication Year :
- 2019
-
Abstract
- Spatial firing of hippocampal place cells varies depending on the animal’s behavior relative to its goals. Here, rats were trained to approach visually guided reward ports in a two-dimensional open field. Hippocampal place cells encoded two independent pieces of information, spatial representation and goal-directed representation, by amplifying firing rates within their place fields specifically while the animal was moving toward a specific goal location. Irrespective of running speed and direction, substantial place-selective firing was observed that sustained a basal spatial map independent of goal-directed signals. When animals were allowed to freely forage in the field, in-field firing rates similarly increased when the animals transiently ran toward remembered goal locations. Disruption of medial septal activity significantly decreased goal-directed firing while maintaining spatial representation patterns. The findings indicate that the integrated encoding of spatial and goal-directed signals by hippocampal circuits is crucial for flexible spatial navigation to a goal location.
Details
- Language :
- English
- ISSN :
- 22111247
- Volume :
- 27
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- Cell Reports
- Publication Type :
- Periodical
- Accession number :
- ejs49929497
- Full Text :
- https://doi.org/10.1016/j.celrep.2019.04.002