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Horisfieldones A and B, Two Aromatic Ring-Contracted Dimeric Diarylpropanes with Human DOPA Decarboxylase Inhibitory Activity from Horsfieldia kingii
- Source :
- Organic Letters; May 2019, Vol. 21 Issue: 10 p3678-3681, 4p
- Publication Year :
- 2019
-
Abstract
- Horisfieldones A (1) and B (2), two dimeric diarylpropanes featuring an unprecedentedly aromatic ring-contracted framework, were isolated from Horsfieldia kingii. Their structures and absolute configurations were determined by the inspection of extensive spectroscopic data and electronic circular dichroism calculations. Molecular modeling analysis, in vitro enzyme-based bioassays, and structure–activity relationship analysis of these isolates revealed that (+)-1(IC50= 35.1 ± 3.9 μM, SI > 11.4) could present a new class of human DOPA decarboxylase inhibitor.
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Volume :
- 21
- Issue :
- 10
- Database :
- Supplemental Index
- Journal :
- Organic Letters
- Publication Type :
- Periodical
- Accession number :
- ejs49925584
- Full Text :
- https://doi.org/10.1021/acs.orglett.9b01125