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Inhibitory effects of sildenafil and tadalafil on inflammation, oxidative stress and nitrosative stress in animal model of bronchial asthma
- Source :
- Pharmacological Reports; June 2019, Vol. 71 Issue: 3 p517-521, 5p
- Publication Year :
- 2019
-
Abstract
- Cyclic neucleotides are involved in many cellular functions including smooth muscle relaxation, inflammation, and signal transduction. Sildenafil and tadalafil are phosphodiesterase-5 (PDE-5) inhibitors which prevent the degradation of cyclic neucleotide i.e.guanosine 3′,5′ cyclic monophosphate (cGMP) and increase the levels of cGMP. In this study sildenafil and tadalafil were evaluated for their anti-inflammatory, anti-oxidative and anti-nitrosative stress potential in animal model of bronchial asthma.
Details
- Language :
- English
- ISSN :
- 17341140
- Volume :
- 71
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Pharmacological Reports
- Publication Type :
- Periodical
- Accession number :
- ejs49851588
- Full Text :
- https://doi.org/10.1016/j.pharep.2019.02.008