Clavukoellians A–F, Highly Rearranged Nardosinane Sesquiterpenoids with Antiangiogenic Activity from Clavulariakoellikeri

Six new nardosinane-type sesquiterpenoids, clavukoellians A–F (1–6), together with one new neolemnane-type sesquiterpene, 4-O-deacetylparalemnolin D (7), were isolated from the marine soft coral Clavularia koellikeri. The structures of compounds 1–7were elucidated by NMR spectroscopy, ECD analysis, and quantum chemical calculation methods. Compounds 1and 7demonstrated significant antiangiogenic activities in wound healing assays on HUVECs.