Two New Aromadendrane Sesquiterpenes from the Stem Bark of Alafia multiflora

Two new aromadendrane sesquiterpenoids (1β,4β,5β,6α,7α,11S)-aromadendr-9-en-13,14-dioic acid (1) and (1β,4β,5β,6α,7α,11S)-13-oxoaromadendr-9-en-14-oic acid (2) have been isolated from the stem bark of Alafia multifloraalong with β-sitosterol and β-sitosterol glucoside. Their structures were established on the basis of spectroscopic analyses, including 1D and 2D NMR experiments (1H-1H COSY, NOESY, HSQC, HMBC). Compound 1showed a weak growth inhibitory activity against the murine melanoma line B16F10 MTT.