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Direct Transformation of Aryl 2-Pyridyl Esters to Secondary Benzylic Alcohols by Nickel Relay Catalysis
- Source :
- Organic Letters; March 2019, Vol. 21 Issue: 7 p2453-2458, 6p
- Publication Year :
- 2019
-
Abstract
- A direct transformation of aryl esters to secondary benzylic alcohols via tandem Ni-catalyzed cross-coupling reactions of aromatic 2-pyridyl esters with alkyl zinc reagents and carbonyl group reduction by Ni–H species is achieved. Preliminary mechanistic studies reveal that the Ni–H species is generated in situvia β-hydride elimination of the Negishi reagents. The reaction is catalyzed by bench-stable nickel salts under mild conditions with wide functional group tolerance.
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Volume :
- 21
- Issue :
- 7
- Database :
- Supplemental Index
- Journal :
- Organic Letters
- Publication Type :
- Periodical
- Accession number :
- ejs49551517
- Full Text :
- https://doi.org/10.1021/acs.orglett.9b00774