Angiotensin type-2 receptors and cardiovascular function are angiotensin type-2 receptors protective?

The renin-angiotensin system is a coordinated hormonal cascade of critical importance to the regulation of blood pressure and cardiovascular function. The major effector peptide, angiotensin II, binds to two major receptors, angiotensin type-1 and angiotensin type-2. Most of the actions of angiotensin II are mediated by the angiotensin type-1 receptor, but recent evidence strongly suggests that the angiotensin type-2 receptor opposes the angiotensin type-1 receptor, particularly by promoting vasodilatation instead of vasoconstriction.