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Increased Expression of Human Leukocyte AntigenDR on Pulmonary Macrophages in Bronchopulmonary Dysplasia
- Source :
- Pediatric Research (Ovid); September 1993, Vol. 34 Issue: 3 p341-344, 4p
- Publication Year :
- 1993
-
Abstract
- We used an immunoperoxidase method to examine the expression of the immune activation marker HLA-DR on pulmonary tissue obtained at autopsy from 14 patients dying of bronchopulmonary dysplasia. Controls consisted of 16 age-matched, sex-matched children dying of noncardiac, nonrespiratory, noninfectious illnesses or as a result of motor vehicle accidents. We did not observe aberrant expression of HLA-DR on pulmonary cndothelial cells. Positive staining appeared exclusively on macrophages. We quantitated the expression of antigen by counting the number of positive macrophages and total macrophages/monocytes per high power field. Bronchopulmonary dysplasia patients displayed significantly greater numbers of both positive and total macrophages compared with the control group (p< 0.05). The percent positive macrophages also was significantly higher in the bronchopulmonary dysplasia patients (p< 0.005). We also examined a group of patients dying with infant respiratory distress syndrome. There was no significant difference in number of total macrophages in this group compared with age-matched controls.
Details
- Language :
- English
- ISSN :
- 00313998 and 15300447
- Volume :
- 34
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Pediatric Research (Ovid)
- Publication Type :
- Periodical
- Accession number :
- ejs49472943