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Clinical and Laboratory Indicators of Extent of Ulcerative Colitis
- Source :
- Journal of Clinical Gastroenterology; February 1988, Vol. 10 Issue: 1 p41-45, 5p
- Publication Year :
- 1988
-
Abstract
- We estimated the extent of the inflammatory mucosal lesion by colonoscopy and biopsy in 60 patients with their first attack of ulcerative colitis. Proctitis was found in 12, proctosig-moiditis in 19, left-sided colitis in 10, and extensive colitis in 19. Fourteen clinical variables and laboratory measurements (bowel frequency, stool consistency, rectal bleeding, fecal mucus/pus, temperature, pulse rate, white blood cell count, hematocrit, sedimentation rate, serum iron, serum albumin, serum α2-globulin, serum C-reactive protein, and seromucoids) were determined. All the variables except rectal bleeding and hematocrit were correlated (p > 0.001) with the extent of colitis. On stepwise discriminant analysis, only C-reactive protein distinguished proctosigmoiditis from more extensive disease at a level of p > 0.001; no other variables improved the discrimination. Cross-validation by the “jack-knife method” showed that 86.7 of patients were correctly classified, the errors consisting in underestimation of disease in 8/29 patients with extensive colitis.
Details
- Language :
- English
- ISSN :
- 01920790 and 15392031
- Volume :
- 10
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Journal of Clinical Gastroenterology
- Publication Type :
- Periodical
- Accession number :
- ejs49421913