Chlorpromazine in Women with Chronic Schizophrenia The Effect on Cholesterol Levels and CholesterolBehavior Relationships

In 2 carefully controlled studies with the same women with chronic schizophrenia, chlorpromazine was shown to raise serum cholesterol levels consistently and significantly. It was also a consistent finding that prior to chlorpromazine therapy cholesterol levels appeared to be related inversely to measures of withdrawal, seclusiveness, and gross psychopathology. After chlorpromazine therapy the cholesterolbehavior relationships were no longer apparent.