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Nasal mucociliary clearance and salmeterol
- Source :
- Clinical Otolaryngology & Allied Sciences; March 1997, Vol. 22 Issue: 1 p68-70, 3p
- Publication Year :
- 1997
-
Abstract
- In vitro studies have suggested that beta 2-adrenergic agents increase the ciliary beat frequency in human respiratory epithelium. We carried out a randomized, double-blind placebo-controlled trial to investigate the effects of a topical spray, salmeterol, on nasal mucociliary clearance using the saccharin test. Thirty-three healthy adults were recruited. There was a 21% reduction of nasal mucociliary transport time of saccharin with salmeterol compared to placebo (P = 0.0001). There was no effect of age, sex, order of treatment, interval between spray and saccharin test, or history of seasonal allergic rhinitis on the improvement in clearance times.
Details
- Language :
- English
- ISSN :
- 03077772 and 13652273
- Volume :
- 22
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Clinical Otolaryngology & Allied Sciences
- Publication Type :
- Periodical
- Accession number :
- ejs4937954
- Full Text :
- https://doi.org/10.1046/j.1365-2273.1997.00882.x