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Summation of peaks and L34 ribosomal protein in the presence and absence of antibiotics enables susceptibility testing using MALDI-TOF mass spectrometry in 2h from Escherichia coli-positive blood cultures

Authors :
Hernández Egido, Sara
Luis Reboredo, Ana de
García Señán, Alicia
Gil González, Ana Belén
Muñoz Bellido, Juan Luis
González Buitrago, José Manual
Sánchez-Juanes, Fernando
Source :
Enfermedades Infecciosas y Microbiología Clínica (ScienceDirect); April 2019, Vol. 37 Issue: 4 p244-250, 7p
Publication Year :
2019

Abstract

We have developed a MALDI-TOF-mediated phenotypic method, which determines antibiotic susceptibility (AS) from positive blood cultures (BCs) in 2h. We developed a software for process automation. We report results on Escherichia coli-positive BCs with cefotaxime (CTX) and ciprofloxacin (CIP).

Details

Language :
English
ISSN :
0213005X and 15781852
Volume :
37
Issue :
4
Database :
Supplemental Index
Journal :
Enfermedades Infecciosas y Microbiología Clínica (ScienceDirect)
Publication Type :
Periodical
Accession number :
ejs49293664
Full Text :
https://doi.org/10.1016/j.eimc.2018.06.017