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PANCREATIC ISLET XENOGRAFT TOLERANCE AFTER SHORT-TERM COSTIMULATION BLOCKADE IS ASSOCIATED WITH INCREASED CD4 T CELL APOPTOSIS BUT NOT IMMUNE DEVIATION1, 2

Authors :
Lehnert, Anne M.
Yi, Shounan
Burgess, Jane S.
O’Connell, Philip J.
Source :
Transplantation; March 2000, Vol. 69 Issue: 6 p1176-1185, 10p
Publication Year :
2000

Abstract

Our purpose was to determine if short-term inhibition of the CD40/CD40L and CD28/B7 costimulatory pathways was capable of inducing specific unresponsiveness to pancreatic islet xenografts and to ascertain the mechanism of tolerance induction.

Details

Language :
English
ISSN :
00411337 and 15346080
Volume :
69
Issue :
6
Database :
Supplemental Index
Journal :
Transplantation
Publication Type :
Periodical
Accession number :
ejs49280048

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