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ROLE OF PLATELET-ACTIVATING FACTOR IN FUNCTIONAL ALTERATIONS INDUCED BY XENOREACTIVE ANTIBODIES IN PORCINE ENDOTHELIAL CELLS1
- Source :
- Transplantation; October 2000, Vol. 70 Issue: 8 p1198-1205, 8p
- Publication Year :
- 2000
-
Abstract
- Platelet-activating factor (PAF) is a phospholipid mediator of inflammation which has been implicated in rejection.The interaction of anti--galactosyl natural antibodies (anti- gal Abs) with endothelial cells is the initial step for the development of xenograft rejection. In our study, we stimulated porcine aorthic endothelial cells (PAEC) with anti- gal IgG to investigate the synthesis of PAF from PAEC and its biological consequences.
Details
- Language :
- English
- ISSN :
- 00411337 and 15346080
- Volume :
- 70
- Issue :
- 8
- Database :
- Supplemental Index
- Journal :
- Transplantation
- Publication Type :
- Periodical
- Accession number :
- ejs49279855