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Significant prolongation of animal survival by combined therapy of FR167653 and cyclosporine A in rat renal allografts
- Source :
- Transplantation; October 2003, Vol. 76 Issue: 7 p1029-1036, 8p
- Publication Year :
- 2003
-
Abstract
- Cyclosporine A (CsA) has improved short-term results in renal transplantation. However, its toxicities have been serious problems in clinical patients undergoing long-term administration. It is necessary to develop a nonnephrotoxic immunosuppressant that allows reducing doses of CsA. The authors tested the effect of a new pyrazolotriazin compound, FR167653 (FR), that inhibits the production of proinflammatory cytokines, using a rat renal acute-rejection model (Wistar-Lewis).
Details
- Language :
- English
- ISSN :
- 00411337 and 15346080
- Volume :
- 76
- Issue :
- 7
- Database :
- Supplemental Index
- Journal :
- Transplantation
- Publication Type :
- Periodical
- Accession number :
- ejs49275683
- Full Text :
- https://doi.org/10.1097/01.TP.0000090392.56694.06