PREDICTION OF MARROW GRAFT REJECTION BY THE LYMPHOCYTEMEDIATED CYTOTOXICITY AND ANTIBODYDEPENDENT CELLMEDIATED CYTOTOXICITY ASSAYS

We previously reported on 26 patients with severe aplastic anemia who were studied using the lymphocyte-mediated cytotoxicity (LMC) and antibody-dependent cell-mediated cytotoxicity (ADCC) assays. Eighty-one additional patients have now been studied. Overall, lymphocytes of 47 of the patients in LMC and sera of 30 in ADCC were reactive against the lymphocytes of HLA-identical siblings. LMC reactivity was more frequent in patients studied < 1 month after diagnosis, but the frequency of ADCC reactivity was unrelated to time after diagnosis.