Transplant Tolerance Associated With a Th1 Response and Not Broken by IL-4, IL-5, and TGF- Blockade or Th1 Cytokine Administration

Authors :: Plain, Karren M.
Boyd, Rochelle
Verma, Nirupama D.
Robinson, Catherine M.
Tran, Giang T.
Hodgkinson, Suzanne J.
Hall, Bruce M.
Source :: Transplantation; March 2007, Vol. 83 Issue: 6 p764-773, 10p
Publication Year :: 2007
Abstract: Specific transplant tolerance is mediated by CD4T cells that die unless supported by T-cell derived cytokines and donor antigen. This study examined the role of Th1 and Th2 cytokines in the maintenance of tolerance.

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