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Intrasplenic Transplantation of Encapsulated Hepatocytes Decreases Mortality and Improves Liver Functions in Fulminant Hepatic Failure from 90% Partial Hepatectomy in Rats
- Source :
- Transplantation; April 2005, Vol. 79 Issue: 7 p783-790, 8p
- Publication Year :
- 2005
-
Abstract
- Encapsulated cell therapy might be a promising approach to enable cell transplantation without immunosuppression. This study investigates the viability and hepatic function of hepatocytes encapsulated with alginate/poly-L-lysine in vitro and the effect of the intrasplenic transplantation of cultured encapsulated hepatocytes on survival in 90% hepatectomized rats as a preliminary step toward allogeneic hepatocyte transplantation without immunosuppression.
Details
- Language :
- English
- ISSN :
- 00411337 and 15346080
- Volume :
- 79
- Issue :
- 7
- Database :
- Supplemental Index
- Journal :
- Transplantation
- Publication Type :
- Periodical
- Accession number :
- ejs49263297
- Full Text :
- https://doi.org/10.1097/01.TP.0000156319.47645.3B