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The Fibrin-Derived Peptide B15-42Significantly Attenuates Ischemia-Reperfusion Injury in a Cardiac Transplant Model

Authors :
Wiedemann, Dominik
Schneeberger, Stefan
Friedl, Peter
Zacharowski, Kai
Wick, Nikolaus
Boesch, Florian
Margreiter, Raimund
Laufer, Guenther
Petzelbauer, Peter
Semsroth, Severin
Source :
Transplantation; April 2010, Vol. 89 Issue: 7 p824-829, 6p
Publication Year :
2010

Abstract

The inflammatory response after prolonged ischemia and subsequent reperfusion leads to increased risk of primary organ dysfunction after cardiac transplantation. It has been demonstrated that the fibrin-derived peptide B15-42(also called FX06) reduces infarct size in coronary artery occlusion/reperfusion models by inhibition of leukocyte migration. Further, B15-42preserves endothelial barrier function. The purpose of this study was to investigate whether B15-42has a protective effect in cardiac allografts exposed to prolonged global ischemia and subsequent in vivo reperfusion.

Details

Language :
English
ISSN :
00411337 and 15346080
Volume :
89
Issue :
7
Database :
Supplemental Index
Journal :
Transplantation
Publication Type :
Periodical
Accession number :
ejs49262099
Full Text :
https://doi.org/10.1097/TP.0b013e3181ccd822