The Fibrin-Derived Peptide B15-42Significantly Attenuates Ischemia-Reperfusion Injury in a Cardiac Transplant Model

The inflammatory response after prolonged ischemia and subsequent reperfusion leads to increased risk of primary organ dysfunction after cardiac transplantation. It has been demonstrated that the fibrin-derived peptide B15-42(also called FX06) reduces infarct size in coronary artery occlusion/reperfusion models by inhibition of leukocyte migration. Further, B15-42preserves endothelial barrier function. The purpose of this study was to investigate whether B15-42has a protective effect in cardiac allografts exposed to prolonged global ischemia and subsequent in vivo reperfusion.