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The Fibrin-Derived Peptide B15-42Significantly Attenuates Ischemia-Reperfusion Injury in a Cardiac Transplant Model
- Source :
- Transplantation; April 2010, Vol. 89 Issue: 7 p824-829, 6p
- Publication Year :
- 2010
-
Abstract
- The inflammatory response after prolonged ischemia and subsequent reperfusion leads to increased risk of primary organ dysfunction after cardiac transplantation. It has been demonstrated that the fibrin-derived peptide B15-42(also called FX06) reduces infarct size in coronary artery occlusion/reperfusion models by inhibition of leukocyte migration. Further, B15-42preserves endothelial barrier function. The purpose of this study was to investigate whether B15-42has a protective effect in cardiac allografts exposed to prolonged global ischemia and subsequent in vivo reperfusion.
Details
- Language :
- English
- ISSN :
- 00411337 and 15346080
- Volume :
- 89
- Issue :
- 7
- Database :
- Supplemental Index
- Journal :
- Transplantation
- Publication Type :
- Periodical
- Accession number :
- ejs49262099
- Full Text :
- https://doi.org/10.1097/TP.0b013e3181ccd822