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Brain Death–Induced Inflammatory Activity in Human Pancreatic Tissue

Authors :
Rech, Tatiana H.
Crispim, Daisy
Rheinheimer, Jakeline
Barkan, Sabrina S.
Osvaldt, Alessandro B.
Filho, Tomaz J.M. Grezzana
Kruel, Cleber R.P.
Martini, Juliano
Gross, Jorge L.
Leitão, Cristiane B.
Source :
Transplantation; January 2014, Vol. 97 Issue: 2 p212-219, 8p
Publication Year :
2014

Abstract

Long-term insulin independence after islet transplantation depends on engraftment of a large number of islets. However, the yield of pancreatic islets from brain-dead donors is negatively affected by the up-regulation of inflammatory mediators. Brain death is also believed to increase tissue factor (TF) expression, contributing to a low rate of engraftment.

Details

Language :
English
ISSN :
00411337 and 15346080
Volume :
97
Issue :
2
Database :
Supplemental Index
Journal :
Transplantation
Publication Type :
Periodical
Accession number :
ejs49259766
Full Text :
https://doi.org/10.1097/TP.0b013e3182a949fa