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Calcineurin Inhibitor-Free Immunosuppressive Regimen in Type 1 Diabetes Patients Receiving Islet Transplantation

Authors :
Maffi, Paola
Berney, Thierry
Nano, Rita
Niclauss, Nadja
Bosco, Domenico
Melzi, Raffaella
Mercalli, Alessia
Magistretti, Paola
De Cobelli, Francesco
Battaglia, Manuela
Scavini, Marina
Demuylder-Mischler, Sandrine
Secchi, Antonio
Piemonti, Lorenzo
Source :
Transplantation; December 2014, Vol. 98 Issue: 12 p1301-1309, 9p
Publication Year :
2014

Abstract

Our final objective is to develop an adoptive therapy with tolerogenic donor-specific type 1 T regulatory cells for patients with type 1 diabetes undergoing islet transplantation. The achievement of this objective depends on the availability of an immunosuppressive treatment compatible with the survival, function, and expansion of type 1 T regulatory cells.

Details

Language :
English
ISSN :
00411337 and 15346080
Volume :
98
Issue :
12
Database :
Supplemental Index
Journal :
Transplantation
Publication Type :
Periodical
Accession number :
ejs49259036
Full Text :
https://doi.org/10.1097/TP.0000000000000396