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Norepinephrine and gammaaminobutyric acid in amyotrophic lateral sclerosis

Authors :
Ziegler, Michael G.
Brooks, Benjamin R.
Lake, C. Raymond
Wood, James H.
Enna, S. J.
Source :
Neurology (Ovid); January 1980, Vol. 30 Issue: 1 p98-101, 4p
Publication Year :
1980

Abstract

Patients with amyotrophic lateral sclerosis have increased levels of the neurotransmitter norepinephrine in blood and cerebrospinal fluid and depressed levels of the inhibitory neurotransmitter gamma-aminobutyric acid in cerebrospinal fluid. These neurochemical alterations are most marked in patients bedridden with advanced disease, appear interrelated, and lead to cardiovascular alterations in patients with amyotrophic lateral sclerosis.

Details

Language :
English
ISSN :
00283878 and 1526632X
Volume :
30
Issue :
1
Database :
Supplemental Index
Journal :
Neurology (Ovid)
Publication Type :
Periodical
Accession number :
ejs49046205