Association of APOEpolymorphisms with disease severity in MS is limited to women

Authors :: Kantarci, O.H.
Hebrink, D.D.
Achenbach, S.J.
Pittock, S.J.
Altintas, A.
Schaefer-Klein, J.L.
Atkinson, E.J.
de Andrade, M.
McMurray, C.T.
Rodriguez, M.
Weinshenker, B.G.
Source :: Neurology (Ovid); March 2004, Vol. 62 Issue: 5 p811-814, 4p
Publication Year :: 2004
Abstract: The authors studied the association of an exon 4 (E42/3/4) and three promoter polymorphisms of APOEwith disease course and severity stratified by gender in 221 patients with multiple sclerosis from two overlapping population-based prevalence cohorts. Women carriers of the E42 allele took longer to attain an Expanded Disability Status Scale score of 6 (p0.015) and had more favorable ranked severity scores than noncarriers (p0.009). There was no association in men. Alleles 3 or 4 and promoter polymorphisms were not associated with disease course or severity.

Full Text Access

Tools