LRRK2mutation analysis in Parkinson disease families with evidence of linkage to PARK8

Pathogenic mutations in the leucine-rich repeat kinase 2 gene (LRRK2) have been found to cause typical, later-onset Parkinson disease (PD). Although G2019S is the most common mutation, other mutations have also been reported. It is critical to catalog the types of mutations found in LRRK2that can cause PD, so as to provide insight regarding disease susceptibility and potential novel treatments.