High insulinlike growth factor I is associated with cognitive decline in Huntington disease

Authors :: Saleh, N.
Moutereau, S.
Azulay, J.-P.
Verny, C.
Simonin, C.
Tranchant, C.
El Hawajri, N.
Bachoud-Lévi, A.-C.
Maison, P.
Source :: Neurology (Ovid); July 2010, Vol. 75 Issue: 1 p57-63, 7p
Publication Year :: 2010
Abstract: The somatotropic axis (growth hormone GH and insulinlike growth factor I IGFI) play a role in the cognitive deficits seen with aging, GH deficiency, and neurodegenerative disorders such as Alzheimer disease. We recently reported elevations in basal plasma GH and IGFI levels in patients with Huntington disease (HD). Here, our objective was to determine whether somatotropic axis abnormalities predicted cognitive dysfunction in HD.

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