Serial MRI and CSF biomarkers in normal aging, MCI, and AD

Authors :: Vemuri, P.
Wiste, H.J.
Weigand, S.D.
Knopman, D.S.
Trojanowski, J.Q.
Shaw, L.M.
Bernstein, M.A.
Aisen, P.S.
Weiner, M.
Petersen, R.C
Jack, C.R
Source :: Neurology (Ovid); July 2010, Vol. 75 Issue: 2 p143-151, 9p
Publication Year :: 2010
Abstract: To compare the annual change in MRI and CSF biomarkers in cognitively normal (CN), amnestic mild cognitive impairment (aMCI), and Alzheimer disease (AD). Comparisons were based on intergroup discrimination, correlation with concurrent cognitive/functional changes, relationships to APOEgenotype, and sample sizes for clinical trials.