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Tau forms in CSF as a reliable biomarker for progressive supranuclear palsySYMBOLSYMBOLSYMBOLSYMBOL
- Source :
- Neurology (Ovid); November 2008, Vol. 71 Issue: 22 p1796-1803, 8p
- Publication Year :
- 2008
-
Abstract
- In CSF, extended (55 kDa) and truncated (33 kDa) tau forms have been previously recognized, and the tau 33 kDa/55 kDa ratio has been found significantly reduced in progressive supranuclear palsy (PSP) vs in other neurodegenerative disorders. The aim of this study was to evaluate the diagnostic value of the CSF tau form ratio as a biomarker of PSP and to correlate the structural anatomic changes as measured by means of voxel-based morphometry (VBM) to CSF tau form ratio decrease.
Details
- Language :
- English
- ISSN :
- 00283878 and 1526632X
- Volume :
- 71
- Issue :
- 22
- Database :
- Supplemental Index
- Journal :
- Neurology (Ovid)
- Publication Type :
- Periodical
- Accession number :
- ejs49020574
- Full Text :
- https://doi.org/10.1212/01.wnl.0000335941.68602.39