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No consistent evidence for association between mtDNA variants and Alzheimer disease

Authors :
Hudson, G.
Sims, R.
Harold, D.
Chapman, J.
Hollingworth, P.
Gerrish, A.
Russo, G.
Hamshere, M.
Moskvina, V.
Jones, N.
Thomas, C.
Stretton, A.
Holmans, P.A.
O'Donovan, M.C.
Owen, M.J.
Williams, J.
Chinnery, P.F.
Harold, Denise
Abraham, Richard
Hollingworth, Paul
Sims, Rebecca
Gerrish, Amy
Chapman, Jade
Russo, Giancarlo
Hamshere, Marian
Pahwa, Jaspreet Singh
Moskvina, Valentina
Dowzell, Kimberley
Williams, Amy
Jones, Nicola
Thomas, Charlene
Stretton, Alexandra
Morgan, Angharad
Lovestone, Simon
Powell, John
Proitsi, Petroula
Lupton, Michelle K
Brayne, Carol
Rubinsztein, David C.
Gill, Michael
Lawlor, Brian
Lynch, Aoibhinn
Morgan, Kevin
Brown, Kristelle
Passmore, Peter
Craig, David
McGuinness, Bernadette
Todd, Stephen
Johnston, Janet
Holmes, Clive
Mann, David
Smith, A. David
Love, Seth
Kehoe, Patrick G.
Hardy, John
Mead, Simon
Fox, Nick
Rossor, Martin
Collinge, John
Maier, Wolfgang
Jessen, Frank
Heun, Reiner
Kölsch, Heike
Schürmann, Britta
van den Bussche, Hendrik
Heuser, Isabella
Kornhuber, Johannes
Wiltfang, Jens
Dichgans, Martin
Frölich, Lutz
Hampel, Harald
Hüll, Michael
Rujescu, Dan
Goate, Alison
Kauwe, John S.K.
Cruchaga, Carlos
Nowotny, Petra
Morris, John C.
Mayo, Kevin
Livingston, Gill
Bass, Nicholas J.
Gurling, Hugh
McQuillin, Andrew
Gwilliam, Rhian
Deloukas, Panagiotis
Holmans, Peter
O'Donovan, Michael
Owen, Michael J.
Williams, Julie
Source :
Neurology (Ovid); April 2012, Vol. 78 Issue: 14 p1038-1042, 5p
Publication Year :
2012

Abstract

Although several studies have described an association between Alzheimer disease (AD) and genetic variation of mitochondrial DNA (mtDNA), each has implicated different mtDNA variants, so the role of mtDNA in the etiology of AD remains uncertain.

Details

Language :
English
ISSN :
00283878 and 1526632X
Volume :
78
Issue :
14
Database :
Supplemental Index
Journal :
Neurology (Ovid)
Publication Type :
Periodical
Accession number :
ejs49019102
Full Text :
https://doi.org/10.1212/WNL.0b013e31824e8f1d