Back to Search
Start Over
In vivo activity of levofloxacin alone or in combination with imipenem or amikacin in a mouse model of Acinetobacter baumannii pneumonia
- Source :
- Journal of Antimicrobial Chemotherapy (JAC); November 2000, Vol. 46 Issue: 5 p827-830, 4p
- Publication Year :
- 2000
-
Abstract
- We evaluated the in vivo activity of levofloxacin alone or in combination with imipenem or amikacin in a mouse model of Acinetobacter baumannii pneumonia using a susceptible strain and one with low-level resistance (MIC/MBC of levofloxacin: 0.06/0.06 and 4/4 mg/L, respectively). As demonstrated previously with other pathogens, the AUC/MIC ratio predicted the efficacy of fluoroquinolones against A. baumannii. This parameter correlated with bactericidal effect and survival. Combination therapy did not enhance the efficacy of levofloxacin.
Details
- Language :
- English
- ISSN :
- 03057453 and 14602091
- Volume :
- 46
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- Journal of Antimicrobial Chemotherapy (JAC)
- Publication Type :
- Periodical
- Accession number :
- ejs4900413