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Nitric oxide regulates NMDAinduced dopamine release in rat striatum
- Source :
- NeuroReport; January 1996, Vol. 7 Issue: 2 p605-608, 4p
- Publication Year :
- 1996
-
Abstract
- We investigated the effect of nitric oxide (NO) on N-methyl-D-aspartate (NMDA)-induced changes in levels of dopamine (DA) and its metabolite in the striatum using in vivomicrodialysis. Local administration of 1 mM NMDA into the striatum significantly augmented DA release in the striatum. Simultaneous administration of 5 mM NG-nitro-L-arginine methyl ester (-NAME), a NO synthase inhibitor, into the striatum significantly potentiated NMDA-induced DA release. This effect of L-NAME was completely reversed in the presence of 50 mM L-arginine (L-Arg). Administration of 1 mM NMDA significantly decreased the levels of dihydrox-yphenylacetic acid (DOPAC) and homovanillic acid (HVA). This effect of NMDA was not affected by concurrent administration of L-NAME. This study provides in vivoevidence for the involvement of NO in NMDA-induced DA release.
Details
- Language :
- English
- ISSN :
- 09594965 and 1473558X
- Volume :
- 7
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- NeuroReport
- Publication Type :
- Periodical
- Accession number :
- ejs48980610