Back to Search
Start Over
Effects of barium on stimulusinduced rises in [K]oin juvenile rat hippocampal area CA1
- Source :
- NeuroReport; August 1998, Vol. 9 Issue: 11 p2583-2587, 5p
- Publication Year :
- 1998
-
Abstract
- IMMATURE glia may not be able to buffer Kions released during neuronal activity. Therefore, we investigated entorhinal-hippocampal slices of juvenile rats (ages P15–18 and P22–26) using a perfusion medium containing 2 mM BaCl2in order to block glial inward rectifying and leak potassium channels. In contrast to adult animals, rises in [K]oin slices from juvenile animals elicited by repetitive alvear stimulation were not augmented by Ba2. Ba2effects on fast field potentials, slow field potentials and the applied current sink source distribution were roughly similar as in adult rats. We conclude that the capacity to buffer large quantities of Kions by mechanisms involving Ba2-sensitive Kchannels has not yet developed in juveniles.
Details
- Language :
- English
- ISSN :
- 09594965 and 1473558X
- Volume :
- 9
- Issue :
- 11
- Database :
- Supplemental Index
- Journal :
- NeuroReport
- Publication Type :
- Periodical
- Accession number :
- ejs48978731