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Pentostatin for the Treatment of Chronic Graft-Versus-Host Disease in Children
- Source :
- Journal of Pediatric Hematology / Oncology; July 2003, Vol. 25 Issue: 7 p584-588, 5p
- Publication Year :
- 2003
-
Abstract
- Chronic graft-versus-host disease (cGVHD) is a major barrier to successful allogeneic stem cell transplantation. Pentostatin has been used to treat cGVHD in a small series of pediatric patients. The authors report the results of the first five pediatric patients receiving pentostatin for refractory cGVHD at Johns Hopkins Hospital. In this early experience, the authors saw considerable symptom response in their patients. Every patient in this series demonstrated a significant improvement in skin and oral symptoms. An increased incidence of infection secondary to pentostatin was not observed. No patient was permanently discontinued from pentostatin subsequent to side effects. If these promising results continue, a trial of pentostatin as a first-line therapy for cGVHD should be considered to potentially reduce our dependence on high-dose steroids for its treatment.
Details
- Language :
- English
- ISSN :
- 10774114 and 15363678
- Volume :
- 25
- Issue :
- 7
- Database :
- Supplemental Index
- Journal :
- Journal of Pediatric Hematology / Oncology
- Publication Type :
- Periodical
- Accession number :
- ejs48929983