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Mixed OsteoclasticPleomorphicType Giant Cell Tumor of the Pancreas with Ductal Adenocarcinoma
- Source :
- Pancreas; August 1997, Vol. 15 Issue: 2 p201-208, 8p
- Publication Year :
- 1997
-
Abstract
- We described a rare form of giant cell tumor of the pancreas composed of mixed osteoclastic/pleomorphic-type giant cell tumor with ductal adenocarcinoma. Immunohistochemical study showed positive staining of cytokeratin and epithelial membrane antigen for pleomorphic-type giant cells and ductal adenocarcinoma but negative for osteoclastic-type giant cells. Vimentin stained positive in both types of giant cells but negative in adenocarcinoma. Osteoclastic-type giant cells were strongly positive for CD68 and tartarate-resistant acid phosphatase was present in these cells, suggesting the osteoclast-like character. CD68 was negative for both pleomorphic-type giant cells and ductal adenocarcinoma. From these findings, we consider that this tumor might be a carcinosarcoma-like neoplasm consisting of both an epithelial and a histiocytic-mesenchymal component.
Details
- Language :
- English
- ISSN :
- 08853177 and 15364828
- Volume :
- 15
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Pancreas
- Publication Type :
- Periodical
- Accession number :
- ejs48924935