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The pharmacokinetic and metabolic profile of olmesartan medoxomil limits the risk of clinically relevant drug interaction
- Source :
- Journal of Hypertension; June 2001, Vol. 19 Issue: Supplement 1 pS21-S32, 12p
- Publication Year :
- 2001
-
Abstract
- Orally administered olmesartan medoxomil was rapidly absorbed from the gastrointestinal tract and converted during absorption to olmesartan, the pharmacologically active metabolite that was subsequently excreted without further metabolism. The medoxomil moiety was released as diacetyl that was rapidly cleared by further metabolism and excretion. Peak plasma concentrations of olmesartan occurred 1–3 h after administration, after which concentrations decreased quickly. The elimination halflife was 10–15 h. Olmesartan medoxomil was not measurable in plasma and excreta. The volume of distribution was low, consistent with limited extravascular tissue distribution.
Details
- Language :
- English
- ISSN :
- 02636352 and 14735598
- Volume :
- 19
- Issue :
- Supplement 1
- Database :
- Supplemental Index
- Journal :
- Journal of Hypertension
- Publication Type :
- Periodical
- Accession number :
- ejs48859575