4D.07

Authors :: Agharazii, M.
Gauthier-Bastien, A.
Ung, R.V.
Mac-Way, F.
Richard, D.
Lariviere, R.
Source :: Journal of Hypertension; June 2015, Vol. 33 Issue: Supplement 1 pe62-e62, 1p
Publication Year :: 2015
Abstract: Increased risk of cardiovascular disease in patients with chronic kidney disease (CKD) has been related to vascular stiffness and isolated systolic hypertension as a result of vascular calcification due to mineral metabolism abnormalities. Using a rat model of CKD with vascular calcification, we found a marked increase in endothelin-1 (ET-1) production in the media of calcified vessels suggesting a role for ET-1. This study was designed to investigate the effect of the ETA receptor antagonist atrasentan on vascular calcification and hemodynamic parameters in CKD rats with mineral metabolism abnormalities.