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Primary Cutaneous T-Cell Lymphoma Positive for Both T-Cell Receptor and T-Cell Receptor
- Source :
- Pathology Case Reviews; July-August 2014, Vol. 19 Issue: 4 p216-220, 5p
- Publication Year :
- 2014
-
Abstract
- Primary cutaneous T-cell lymphomas ( CTCLs) was first described in 1991, and in 2008, it was classified as a provisional form of cutaneous T-cell lymphoma by the World Health Organization. This is considered a highly aggressive lymphoma, and because of the rarity and lack of clearly defined diagnostic features, it can represent a considerable diagnostic challenge. Diagnosis of CTCL requires demonstration of the T-cell receptor (TCR) and absence of the TCR. Until recently, no reliable antibody for formalin-fixed paraffin-embedded sections against the TCR existed, and most CTCLs were diagnosed in absence of the TCR- and presence of a compatible cytotoxic immunophenotype (CD4−CD8−, granzyme). However, because some lymphomas are TCR silent and thus not belonging to the -lineage, this approach should not stand alone. We present a case of CTCL that illustrates the difficulties in diagnosing this type of lymphoma both histopathologically and clinically. This case was particularly challenging because the neoplastic T cells displayed immunohistochemical positivity for both TCR- and TCR-. Therefore, TCR- may be aberrantly expressed in CTCL, and positive staining for TCR- alone cannot be used to exclude the diagnosis of CTCL.
Details
- Language :
- English
- ISSN :
- 10829784 and 15334015
- Volume :
- 19
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- Pathology Case Reviews
- Publication Type :
- Periodical
- Accession number :
- ejs48775688
- Full Text :
- https://doi.org/10.1097/PCR.0000000000000047