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Construction of Benzofuran-3(2H)-one Scaffolds with a Quaternary Center via Rh/Co Relay Catalyzed C–H Functionalization/Annulation of N-Aryloxyacetamides and Propiolic Acids
- Source :
- Organic Letters; March 2019, Vol. 21 Issue: 6 p1654-1658, 5p
- Publication Year :
- 2019
-
Abstract
- An unprecedented synthesis of valuable benzofuran-3(2H)-one scaffolds with a quaternary center was developed via Rh/Co relay catalyzed C–H functionalization/annulation of N-aryloxyacetamides with propiolic acids in moderate to good yields. The reaction features the simultaneous construction of the benzofuran motif containing a C2 quaternary center and a C3 carbonyl group. The preliminary mechanism study verified that the O atom of C3 carbonyl group originates from molecular oxygen.
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Volume :
- 21
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Organic Letters
- Publication Type :
- Periodical
- Accession number :
- ejs48775092
- Full Text :
- https://doi.org/10.1021/acs.orglett.9b00181